イシイ ヤスオ
石井 泰雄 所属 統合教育学修センター 統合教育学修センター 職種 講師 |
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論文種別 | 原著 |
言語種別 | 英語 |
査読の有無 | 査読あり |
表題 | Chx10 functions as a regulator of molecular pathways controlling the regional identity in the primordial retina. |
掲載誌名 | 正式名:Developmental biology 略 称:Dev Biol ISSNコード:(1095-564X)0012-1606(Linking) |
掲載区分 | 国外 |
巻・号・頁 | 413(1),pp.104-11 |
著者・共著者 | Wang Zi, Yasugi Sadao, Ishii Yasuo |
担当区分 | 最終著者,責任著者 |
発行年月 | 2016/05 |
概要 | The light-sensitive neural retina (NR) and the retinal pigmented epithelium (RPE) develop from a common primordium, the optic vesicle, raising the question of how they acquire and maintain distinct identities. Here, we demonstrate that sustained misexpression of the Chx10 homeobox gene in the presumptive RPE in chick suppresses accumulation of melanin pigments and promotes ectopic NR-like neural differentiation. This phenotypic change involved ectopic expression of NR transcription factor genes, Sox2, Six3, Rx1 and Optx2, which, when misexpressed, counteracted RPE development without upregulating Chx10. These results suggest that Chx10 can function as a cell autonomous regulator of the regional identity in the primordial retina, presumably through a downstream transcriptional cascade. |
DOI | 10.1016/j.ydbio.2016.03.023 |
PMID | 27001188 |