SAITO Taiichi
   Department   Research Institutes and Facilities, Research Institutes and Facilities
   Position  
Article types Original article
Language English
Peer review Peer reviewed
Title Apparent diffusion coefficient of human brain tumors at MR imaging.
Journal Formal name：Radiology
Abbreviation：Radiology
ISSN code：0033-8419(Print)0033-8419(Linking)
Domestic / ForeginForegin
Volume, Issue, Page 235(3),pp.985-91
Author and coauthor Yamasaki Fumiyuki, Kurisu Kaoru, Satoh Kenichi, Arita Kazunori, Sugiyama Kazuhiko, Ohtaki Megu, Takaba Junko, Tominaga Atushi, Hanaya Ryosuke, Yoshioka Hiroyuki, Hama Seiji, Ito Yoko, Kajiwara Yoshinori, Yahara Kaita, Saito Taiichi, Thohar Muhamad A
Publication date 2005/06
Summary PURPOSE:To determine if apparent diffusion coefficient (ADC) can be used to differentiate brain tumors at magnetic resonance (MR) imaging.MATERIALS AND METHODS:Institutional review board approval or informed patient consent was not required. MR images were reviewed retrospectively in 275 patients with brain tumors: 147 males and 128 females 1-81 years old, treated between September 1997 and July 2003. Regions of interest were placed manually in tumor regions on MR images, and ADC was calculated with a five-point regression method at b values of 0, 250, 500, 750, and 1000 sec/mm2. ADC values were average values in tumor. All brain tumor subgroups were analyzed. Logistic discriminant analysis was performed by using ADC, age, and patient sex as independent variables to discriminate among tumor groups.RESULTS:A significant negativeRESULTS:correlation existed between ADC and astrocytic tumors of World Health Organization grades 2-4 (grade 2 vs grades 3 and 4, accuracy of 91.3% [PRESULTS:<RESULTS:.01RESULTS:]RESULTS:; grade 3 vs 4, accuracy of 82.4% [PRESULTS:<RESULTS:.01RESULTS:]RESULTS:). ADC of dysembryoplastic neuroepithelial tumors (DNTs) was higher than that of astrocytic grade 2 tumors (accuracy, 100%) and other glioneuronal tumors. ADC of malignant lymphomas was lower than that of glioblastomas and metastatic tumors (accuracy, 83.6%; PRESULTS:<RESULTS:.01). ADC of primitive neuroectodermal tumors (PNETs) was lower than that of ependymomas (accuracy, 100%). ADC of meningiomas was lower than that of schwannomas (accuracy, 92.4%; PRESULTS:<RESULTS:.01). ADC of
DOI 10.1148/radiol.2353031338
Document No. 15833979