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論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Detection and differentiation of lactate and lipids by single-voxel proton MR spectroscopy.
掲載誌名	正式名：Neurosurgical review 略　 称：Neurosurg Rev ISSNコード：0344-5607(Print)0344-5607(Linking)
掲載区分	国外
巻・号・頁	28(4),pp.267-77
著者・共著者	Yamasaki Fumiyuki, Takaba Junko, Ohtaki Megu, Abe Nobukazu, Kajiwara Yoshinori, Saito Taiichi, Yoshioka Hiroyuki, Hama Seiji, Akimitsu Tomohide, Sugiyama Kazuhiko, Arita Kazunori, Kurisu Kaoru
発行年月	2005/10
概要	The signals of lactate and lipids partially overlap in single-voxel proton MR spectroscopy (1HMRS), sometimes making them difficult to differentiate in clinical settings. Our aim in this study was to identify lactate and lipids by varying the echo time (TE). We expect that the accurate detection of lactate and lipids will have high diagnostic value in the diagnosis of brain tumors. Following our protocol, we obtained meaningful 1HMRS spectra from 213 patients, including 163 patients with brain tumors, between August 1999 and February 2004. 1HMRS was performed with a TE of 144 ms followed by a TE of 30 ms and/or a TE of 288 ms, if necessary. For the 213 patients, lactate level was"negative"in 47 patients,"positive"in 131 patients, and"strongly positive"in 35 patients. The lipid level was"negative"in 90 patients,"positive"in 56 patients, and"strongly positive"in 67 patients. Based on logistic discriminant analyses of neuro-epithelial tumor WHO grade and lactate and lipid levels, lactate and lipid levels were significant between WHO grades 2 and 3 (P=0.0239) and between grades 3 and 4 (P=0.0347). Lipids are a more significant factor for the discrimination between WHO grades 2 and 3 (P=0.0073) and between grades 3 and 4 (P=0.0048). With our method of varying the TE, it is possible accurately and efficiently to detect lactate and lipids in the brain. We found a significant correlation between lactate and lipid expression and WHO grade of neuro-epithelial tumors.
DOI	10.1007/s10143-005-0398-1
文献番号	16133454