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SAITO Taiichi
Department Research Institutes and Facilities, Research Institutes and Facilities Position |
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| Article types | Original article |
| Language | English |
| Peer review | Peer reviewed |
| Title | Cytoplasmic, but not nuclear, p16 expression may signal poor prognosis in high-grade astrocytomas. |
| Journal | Formal name：Journal of neuro-oncology Abbreviation：J Neurooncol ISSN code：0167-594X(Print)594X(Linking) |
| Domestic / Foregin | Foregin |
| Volume, Issue, Page | 77(3),pp.273-7 |
| Author and coauthor | Arifin Muhamad Thohar, Hama Seiji, Kajiwara Yoshinori, Sugiyama Kazuhiko, Saito Taiichi, Matsuura Shinya, Yamasaki Fumiyuki, Arita Kazunori, Kurisu Kaoru |
| Publication date | 2006/05 |
| Summary | BACKGROUND:The negative consequences of the cytoplasmic localization of p16 in patients with high-grade astrocytomas, on their prognosis, was investigated.METHODS:p16 Expression was examined in 20 anaplastic astrocytoma and 42 glioblastoma patients by immunohistochemical analysis, and the relationship between both cytoplasmic and nuclear p16 expression and prognosis analyzed.RESULTS:The cytoplasmic expression of p16 statistically correlated with poor prognosis. On the other hand, no correlation was observed between p16 nuclear expression and patient survival.CONCLUSION:The cytoplasmic immunoreactivity of p16 appears to be an unfavorable prognostic indicator in high-grade astrocytoma patients. The localization of p16 expression should be determined when evaluating the prognosis of these patients. |
| DOI | 10.1007/s11060-005-9037-5 |
| Document No. | 16614947 |