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SAITO Taiichi
Department Research Institutes and Facilities, Research Institutes and Facilities Position |
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| Article types | Original article |
| Language | English |
| Peer review | Peer reviewed |
| Title | Prognosis of cerebellar glioblastomas: correlation between prognosis and immunoreactivity for epidermal growth factor receptor compared with supratentorial glioblastomas. |
| Journal | Formal name：Anticancer research Abbreviation：Anticancer Res ISSN code：0250-7005(Print)0250-7005(Linking) |
| Domestic / Foregin | Foregin |
| Volume, Issue, Page | 26(2B),pp.1351-7 |
| Author and coauthor | Saito Taiichi, Hama Seiji, Kajiwara Yoshinori, Sugiyama Kazuhiko, Yamasaki Fumiyuki, Arifin Muhamad-Thohar, Arita Kazunori, Kurisu Kaoru |
| Publication date | 2007/04 |
| Summary | BACKGROUND:Cerebellar glioblastomas (GBM) are rare tumors whose clinicopathological characteristics are not well understood.PATIENTS AND METHODS:Clinico-immunohistochemical findings were retrospectively analyzed in 43 supratentorial- and 7 cerebellar GBM. The correlation between survival and immunopositivity for p53, epidermal growth factor receptor (EGFR) and Ki-67 in these tumors was statistically analyzed and compared.RESULTS:Of the 43 patients with supratentorial GBM, 27 (62.8%) were EGFR immunopositive; their survival was significantly shorter than that of the 16 EGFR-negative patieRESULTS:nts (p=0.0248). There was no significant correlation between survival and p53 immunopositivity (p=0.7870) and Ki-67 labeling index (p =0.7133). All 5 cerebellar GBM patients treated with radio- and chemotherapy were EGFR-immunonegative; they survived significantly longer than patients with supratentorial GBM (p=0.0296) possibly because their EGFR negativity rendered their tumors more highly radiosensitive.CONCLUSION:The better prognosis of patients with cerebellar, EGFR-negative tumors compared to patients with supratentorial tumors is due to the higher radiosensitivity of these tumors. |
| Document No. | 16619544 |