サイトウ　タイイチ   齋藤　太一    所属   研究施設 研究施設    職種   非常勤講師
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Prognosis of cerebellar glioblastomas: correlation between prognosis and immunoreactivity for epidermal growth factor receptor compared with supratentorial glioblastomas.
掲載誌名	正式名：Anticancer research 略　 称：Anticancer Res ISSNコード：0250-7005(Print)0250-7005(Linking)
掲載区分	国外
巻・号・頁	26(2B),pp.1351-7
著者・共著者	Saito Taiichi, Hama Seiji, Kajiwara Yoshinori, Sugiyama Kazuhiko, Yamasaki Fumiyuki, Arifin Muhamad-Thohar, Arita Kazunori, Kurisu Kaoru
発行年月	2007/04
概要	BACKGROUND:Cerebellar glioblastomas (GBM) are rare tumors whose clinicopathological characteristics are not well understood.PATIENTS AND METHODS:Clinico-immunohistochemical findings were retrospectively analyzed in 43 supratentorial- and 7 cerebellar GBM. The correlation between survival and immunopositivity for p53, epidermal growth factor receptor (EGFR) and Ki-67 in these tumors was statistically analyzed and compared.RESULTS:Of the 43 patients with supratentorial GBM, 27 (62.8%) were EGFR immunopositive; their survival was significantly shorter than that of the 16 EGFR-negative patieRESULTS:nts (p=0.0248). There was no significant correlation between survival and p53 immunopositivity (p=0.7870) and Ki-67 labeling index (p =0.7133). All 5 cerebellar GBM patients treated with radio- and chemotherapy were EGFR-immunonegative; they survived significantly longer than patients with supratentorial GBM (p=0.0296) possibly because their EGFR negativity rendered their tumors more highly radiosensitive.CONCLUSION:The better prognosis of patients with cerebellar, EGFR-negative tumors compared to patients with supratentorial tumors is due to the higher radiosensitivity of these tumors.
文献番号	16619544