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SAITO Taiichi
Department Research Institutes and Facilities, Research Institutes and Facilities Position |
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| Article types | Original article |
| Language | English |
| Peer review | Peer reviewed |
| Title | Survivin subcellular localization in high-grade astrocytomas: simultaneous expression in both nucleus and cytoplasm is negative prognostic marker. |
| Journal | Formal name：Journal of neuro-oncology Abbreviation：J Neurooncol ISSN code：0167-594X(Print)0167-594X(Linking) |
| Domestic / Foregin | Foregin |
| Volume, Issue, Page | 82(2),pp.193-8 |
| Author and coauthor | Saito Taiichi, Arifin Muhamad Thohar, Hama Seiji, Kajiwara Yoshinori, Sugiyama Kazuhiko, Yamasaki Fumiyuki, Hidaka Toshikazu, Arita Kazunori, Kurisu Kaoru |
| Publication date | 2007/04 |
| Summary | OBJECTIVE:Subcellularly localized (nuclear and/or cytoplasmic) survivin has various functions, and correlates with prognosis of malignant tumors. However, there have been no reports about the significance of subcellularly localized survivin in high-grade astrocytomas. The aim of the present study was to examine the relationship between prognosis and subcellular localization of survivin in high-grade astrocytoma.METHODS:We immunohistochemically examined the pattern of subcellular localization of survivin expression (nuclear, cytoplasmic, or both) in 51 patients with high-grade astrocytoma (19 anaplastic astrocytomas; 32 glioblastomas). We statistically examined the relationship between survivin localization and prognosis, using multivariate analysis including other clinicopathological factors (age, sex, WHO grade, extent of resection, MIB-1 labeling index, and expression of p53 and epidermal growth factor receptor).RESULTS:All specimens stained positive for survivin: localized in nucleus only (nuclear-positive group), 10 cases (20%); localized in cytoplasm only (cytoplasmic-positive group), 23 cases (45%); simultaneous expression in nucleus and cytoplasm (nuclear-cytoplasmic group), 19 cases (35%). There was no significant difference in prognosis between the nuclear-positive group and cytoplasmic-positive group (P=0.796). However, the nuclear-cytoplasmic group had significantly shorter overall survival than the nuclear-positive group and the cytoplasmic-positive group (PRESULTS:<RESULTS:0.0001).CONCLUSIONS:We found that simultaneous expression of survivin in both the nucleus and cytoplasm is an important prognostic factor for high-grade astrocytoma. The present findings indicate that subcellular localization of survivin expression is a reliable prognostic factor for patients with this tumor. |
| DOI | 10.1007/s11060-006-9267-1 |
| Document No. | 17151933 |