熊切 順
   Department   School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine
   Position   Professor
Article types Case report
Language English
Peer review Peer reviewed
Title Should sexual intercourse be avoided during the embryo transfer cycle? Life-threatening ruptured heterotopic pregnancy after single thawed embryo transfer: case report and review of the literature.
Journal Formal name:Clinical and experimental obstetrics & gynecology
Abbreviation:Clin Exp Obstet Gynecol
ISSN code:03906663/03906663
Domestic / ForeginForegin
Volume, Issue, Page 44(3),pp.489-491
Author and coauthor Aoki Y, Kumakiri J, Itakura A, Kikuchi I, Takahashi N, Satoru T
Publication date 2017
Summary BACKGROUND:To report the life-threatening complication of a raptured heterotopic pregnancy occurring from thawed single embryo transfer.CASE REPORT:A 33-year-old woman underwent in vitro fertilization (IVF) under a step-up regimen. After oocyte collection, blastocysts were frozen, and a single frozen-thawed blastocyst was then transferred according to the natural cycle. On day 17 after embryo transfer, an intrauterine pregnancy was confirmed. On day 28, she complained of sudden abdominal pain and ultrasonography revealed marked fluid retention in the peritoneal cavity. Emergency laparoscopy was performed, revealing hemoperitoneum and a ruptured interstitial heterotopic pregnancy (HP), which was then resected laparoscopically. Because sexual intercourse had occurred shortly before the transfer, a HP comprising a spontaneous pregnancy and a pregnancy achieved by assisted reproductive technology was assumed. The fetus in the uterus survived and was delivered.CONCLUSION:In this case, however, despite the single embryo transfer during the natural-cycle frozen-thawed embryo transfer process, the risk of life-threatening complication as a HP as a consequence of spontaneous pregnancy after sexual intercourse remained.
PMID 29949304