クマキリ　ジユン   熊切　順    所属   医学部 医学科（東京女子医科大学病院）    職種   教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	The opioid neuropeptides in uterine fibroid pseudocapsules: a putative association with cervical integrity in human reproduction.
掲載誌名	正式名：Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 略　 称：Gynecol Endocrinol ISSNコード：14730766/09513590
掲載区分	国外
巻・号・頁	29(11),pp.982-8
著者・共著者	Malvasi Antonio, Cavallotti Carlo, Nicolardi Giuseppe, Pellegrino Marcello, Vergara Daniele, Greco Marilena, Kosmas Ioannis, Mynbaev Ospan A, Kumakiri Jun, Tinelli Andrea
発行年月	2013/11
概要	The myoma pseudocapsule (MP) is a fibro-vascular network rich of neurotransmitters, as a neurovascular bundle, surrounding fibroid and separating myoma from myometrium. We investigated the distribution of the opioid neuropeptides, as enkephalin (ENK) and oxytocin (OXT), in the nerve fibers within MP and their possible influence in human reproduction in 57 women. An histological and immunofluorescent staining of OXT and ENK was performed on nerve fibers of MP samples from the fundus, corpus and isthmian-cervical regions, with a successive morphometric quantification of OXT and ENK. None of the nerve fibers in the uterine fundus and corpus MPs contained ENK and the nerve fibers in the isthmian-cervical region demonstrated an ENK value of up to 94 ± 0.7 CU. A comparatively lower number of OXT-positive nerve fibers were found in the fundal MP (6.3 ± 0.8 CU). OXT-positive nerve fibers with OXT were marginally increased in corporal MP (15.0 ± 1.4 CU) and were substantially higher in the isthmian-cervical region MP (72.1 ± 5.1 CU) (p < 0.01). The distribution of OXY neurofibers showed a slight into the uterine corpus, while are highly present into the cervico-isthmic area, with influence on reproductive system and sexual disorders manifesting after surgical procedures on the cervix.
DOI	10.3109/09513590.2013.824958
PMID	23937196