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熊切 順
Department School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine Position Professor |
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| Article types | Original article |
| Language | English |
| Peer review | Peer reviewed |
| Title | Adhesion-prevention effects of fibrin sealants after laparoscopic myomectomy as determined by second-look laparoscopy: a prospective, randomized, controlled study. |
| Journal | Formal name：The Journal of reproductive medicine Abbreviation：J Reprod Med ISSN code：00247758/00247758 |
| Domestic / Foregin | Foregin |
| Volume, Issue, Page | 50(8),pp.571-7 |
| Author and coauthor | Takeuchi Hiroyuki, Kitade Mari, Kikuchi Iwaho, Shimanuki Hiroto, Kumakiri Jun, Kinoshita Katsuyuki |
| Publication date | 2005/08 |
| Summary | OBJECTIVE:To examine the adhesion prevention effects of 2 types of fibrin sealant after laparoscopic myomectomy (LM).STUDY DESIGN:A prospective, randomized study (Canadian Task Force I) was conducted at a University-affiliated hospital. A total of 91 patients showing a minimal myoma > 5 cm, excluding pedunculated myomas, underwent LM alone: 32 patients in the control group, 29 in the fibrin gel group and 30 patients in the fibrin sheet group. After LM, postoperative adhesions were evaluated by second-look laparoscopy. The frequency of postoperative adhesions was the main outcome.RESULTS:The frequency of postoperative adhesions of the uterus was significantly lower (p < 0.05) in the fibrin gel group, with 20/32 (62.5%) in the control group, 10/29 (34.5%) in the fibrin gel group and 20/30 (67.7%) in the fibrin sheet group. Although no significant differences were found in the incidence of de novo adnexal adhesions, the lowest rate was found in the fibrin gel group, with 4/32 patients (12.5%) in the control group, 2/29 patients (6.8%) in the fibrin gel group and 5/30 patients (16.7%) in the fibrin sheet group. No bilateral adnexal adhesions were observed in the 3 groups.CONCLUSION:After LM for myomas as large as > or = 5 cm, postoperative adhesions were observed in > or = 50% of patients. The use of fibrin gel after LM is recommended. |
| PMID | 16220761 |