YAMASHITA Shingo
   Department   School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine
   Position   Assistant Professor
Article types Original article
Language English
Peer review Non peer reviewed
Title Significance of a preoperative tumor marker gradient for predicting microvascular invasion in cases of hepatocellular carcinoma.
Journal Formal name：Molecular and clinical oncology
Abbreviation：Mol Clin Oncol
ISSN code：20499450/20499450
Domestic / ForeginForegin
Volume, Issue, Page 12(3),pp.290-294
Author and coauthor Koizumi Satoshi, Yamashita Shingo, Matsumura Satoshi, Takeda Kazuhisa, Minagawa Takuya, Kobayashi Shinjiro, Hibi Taizo, Shinoda Masahiro, Endo Itaru, Tanabe Minoru, Yamamoto Masakazu, Otsubo Takehito
Publication date 2020/03
Summary Although vascular invasion is an important factor in the progression and treatment of hepatocellular carcinoma (HCC), it remains difficult to determine, on the basis of preoperative imaging alone, whether vascular invasion, especially microvascular invasion, has occurred. The current retrospective study enrolled 292 patients who, between 2004 and 2014, underwent curative hepatectomy as an initial treatment for HCC. The patients were divided between those with (n=70) and those without (n=222) microvascular invasion. Whether tumor-marker-based prediction of microvascular invasion was possible was assessed by comparing the preoperative serum α-fetoprotein (AFP) and prothrombin induced by vitamin K absence or antagonist-II concentrations between two groups of patients. The AFP concentration was significantly higher in patients with microvascular invasion compared with patients without microvascular invasion (P=0.0019). Stepwise logistic regression analysis demonstrated the AFP concentration and the logarithmic conversion ratio of the AFP gradient (log AFP grad) to be useful (P=0.0019; 0.0424) for predicting microvascular invasion. The serum AFP concentration and log AFP grad appear to be clinically useful in predicting microvascular invasion in patients with HCC.
DOI 10.3892/mco.2020.1975
PMID 32064109