ヤマシタ　シンゴ   YAMASHITA Shingo   山下　信吾    所属   医学部 医学科（東京女子医科大学病院）    職種   助教
論文種別	原著
言語種別	英語
査読の有無	査読なし
表題	Significance of a preoperative tumor marker gradient for predicting microvascular invasion in cases of hepatocellular carcinoma.
掲載誌名	正式名：Molecular and clinical oncology 略　 称：Mol Clin Oncol ISSNコード：20499450/20499450
掲載区分	国外
巻・号・頁	12(3),pp.290-294
著者・共著者	Koizumi Satoshi, Yamashita Shingo, Matsumura Satoshi, Takeda Kazuhisa, Minagawa Takuya, Kobayashi Shinjiro, Hibi Taizo, Shinoda Masahiro, Endo Itaru, Tanabe Minoru, Yamamoto Masakazu, Otsubo Takehito
発行年月	2020/03
概要	Although vascular invasion is an important factor in the progression and treatment of hepatocellular carcinoma (HCC), it remains difficult to determine, on the basis of preoperative imaging alone, whether vascular invasion, especially microvascular invasion, has occurred. The current retrospective study enrolled 292 patients who, between 2004 and 2014, underwent curative hepatectomy as an initial treatment for HCC. The patients were divided between those with (n=70) and those without (n=222) microvascular invasion. Whether tumor-marker-based prediction of microvascular invasion was possible was assessed by comparing the preoperative serum α-fetoprotein (AFP) and prothrombin induced by vitamin K absence or antagonist-II concentrations between two groups of patients. The AFP concentration was significantly higher in patients with microvascular invasion compared with patients without microvascular invasion (P=0.0019). Stepwise logistic regression analysis demonstrated the AFP concentration and the logarithmic conversion ratio of the AFP gradient (log AFP grad) to be useful (P=0.0019; 0.0424) for predicting microvascular invasion. The serum AFP concentration and log AFP grad appear to be clinically useful in predicting microvascular invasion in patients with HCC.
DOI	10.3892/mco.2020.1975
PMID	32064109