ヒグチ　リヨウタ   HIGUCHI Ryota   樋口　亮太    所属   医学部 医学科（附属八千代医療センター）    職種   講師
論文種別	原著
言語種別	英語
査読の有無	査読なし
表題	Impact of S-1 adjuvant chemotherapy longer than 6 months on survival in patients with resected pancreatic cancer: a nationwide survey by the Japan Pancreas Society based on real-world data.
掲載誌名	正式名：Cancer 略　 称：Cancer ISSNコード：10970142/0008543X
掲載区分	国外
巻・号・頁	129(5),pp.728-739
著者・共著者	TOMIMARU Yoshito, EGUCHI Hidetoshi, INOUE Yosuke, NAGAKAWA Yuichi, OHBA Akihiro, TAKAMI Hideki, UNNO Michiaki, Yamamoto Tomohisa, KAWATSU Shoji, HAYASHI Tsuyoshi, HIGUCHI Ryota, KITAGAWA Hirohisa, HATTORI Satoshi, FUJII Tsutomu, HIROOKA Yoshiki, IGARASHI Hisato, KITANO Masayuki, KUROKI Tamotsu, MASAMUNE Atsushi, SHIMIZU Yasuhiro, TANI Masaji, TANNO Satoshi, TSUJI Yoshihisa, YAMAUE Hiroki, SATOI Sohei, TAKEYAMA Yoshifumi,
発行年月	2023/03
概要	BACKGROUND:Based on the Japan Adjuvant Study Group of Pancreatic Cancer 01 study, the standard duration of adjuvant chemotherapy with S-1 (an oral 5-fluorouracil prodrug consisting of tegafur, gimeracil, and oteracil) in patients with resected pancreatic ductal adenocarcinoma (PDAC) was considered to be 6 months, but the impact of increasing its duration on postoperative survival was unknown. Here, the authors investigated this question by reviewing real-world data from a large cohort of patients with PDAC.METHODS:In total, 3949 patients who underwent surgery for PDAC during the study period followed by S-1 adjuvant chemotherapy in board-certified institutions were included. Based on the duration of S-1 chemotherapy, two subgroups were defined: a standard-duration group that included patients who were treated for 180 ± 30 days and a longer duration group that included patients who received treatment for >210 days.RESULTS:The median duration of S-1 chemotherapy was 167 days, with a mean ± standard deviation of 200 ± 193 days. After excluding patients who had a recurrence within 210 days after the initiation of adjuvant chemotherapy, postoperative recurrence-free survival (RFS) and overall survival (OS) in the standard-duration group (n = 1473) and the longer duration group (n = 975) were compared. RFS and OS did not differ significantly between the standard-duration and longer duration groups (5-year RFS: 37.8% vs. 36.2% respectively; p = .6186; 5-year OS: 52.8% vs. 53.4%, respectively; p = .5850). The insignificant difference was verified by multivariate analysis and propensity-score matching analysis.CONCLUSIONS:The current findings suggest that extending S-1 adjuvant chemotherapy beyond 6 months has no significant additional effect on survival in patients with PDAC. This could be useful in determining whether to extend S-1 chemotherapy in patients who have completed the standard 6-month treatment.
DOI	10.1002/cncr.34580
PMID	36504020