ヒグチ　リヨウタ   HIGUCHI Ryota   樋口　亮太    所属   医学部 医学科（附属八千代医療センター）    職種   講師
論文種別	原著
言語種別	英語
査読の有無	査読なし
表題	Postoperative Treatment of Resectable Pancreatic Cancer With Positive Peritoneal Lavage Cytology: A Multicentre Retrospective Study.
掲載誌名	正式名：Anticancer research 略　 称：Anticancer Res ISSNコード：17917530/02507005
掲載区分	国外
巻・号・頁	42(2),pp.893-902
著者・共著者	Todaka Akiko, Nara Satoshi, Motoi Fuyuhiko, Morinaga Soichiro, Toshiyama Reishi, Higuchi Ryota, Konishi Masaru, Shirakawa Hirofumi, Tsumura Hidetaka, Okuyama Hiroyuki, Nagano Hiroaki, Shioji Kazuhiko, Sugimachi Keishi, Asagi Akinori, Mizuno Nobumasa, Furuse Junji
発行年月	2022/02
概要	BACKGROUND/AIM:We aimed to evaluate pancreatic cancer (PC) with positive peritoneal lavage cytology (CY1) outcomes following a change in adjuvant therapy.PATIENTS AND METHODS:The clinicopathological data of patients with pancreatic adenocarcinoma with CY1 at 14 institutions, between 2007 and 2015, were collected and analyzed.RESULTS:Of the 124 eligible patients, 114 underwent macroscopically curative resection. Of the 114 patients, 80 (70%) did not have early recurrence and received postoperative chemotherapy that was S-1 in 43 (54%), gemcitabine in 31 (39%), and others in six (7%). The median overall survival was 21.0 months in S-1 and 19.2 in gemcitabine therapy (p=0.23), whereas the median relapse-free survival was 10.2 and 7.1 months (p=0.03), respectively.CONCLUSION:Following the change in adjuvant therapy, most PC patients with CY1 who underwent macroscopically curative resection received S-1; however, it was insufficient. Further development of postoperative chemotherapy is required.
DOI	10.21873/anticanres.15547
PMID	35093887