HIGUCHI Ryota    Department   School of Medicine(Yachiyo Medical Center), School of Medicine    Position   Assistant Professor
Article types	Original article
Language	English
Peer review	Non peer reviewed
Title	Comparison of Clinicopathological Features of Biliary Neuroendocrine Carcinoma with Adenocarcinoma.
Journal	Formal name：Digestive surgery Abbreviation：Dig Surg ISSN code：14219883/02534886
Domestic / Foregin	Foregin
Volume, Issue, Page	38(1),pp.30-37
Author and coauthor	SHIIHARA Kimihiro, HIGUCHI Ryota, FURUKAWA Toru, YAZAWA Takehisa, UEMURA Shuichiro, IZUMO Wataru, YAMAMOTO Masakazu
Authorship	2nd author
Publication date	2021/01
Summary	OBJECTIVE:This study aimed to demonstrate the clinical features and postoperative outcomes of extrahepatic bile duct (EHBD) neuroendocrine carcinoma (NEC) and compared with those of adenocarcinoma.METHODS:We retrospectively analyzed patients with EHBD cancer operated in our institution between 1995 and 2015.RESULTS:Of 475 patients, 468 had adenocarcinoma, while 7 had NEC/mixed adenoneuroendocrine carcinoma (MANEC) in this study. There were no notable preoperative and pathological features in patients with NEC/MANEC. However, patients with NEC/MANEC had a higher recurrence rate (51.8 vs. 100%, p = 0.016), poorer relapse-free survival (RFS) time (the median RFS time: 35 vs. 12 months, p = 0.006), and poorer overall survival (OS) time (the median OS time: 60 vs. 19 months, p = 0.078) than those with adenocarcinoma. Furthermore, patients with NEC/MANEC had higher rates of liver metastasis (11.9 vs. 85.7%, p < 0.001) than those with adenocarcinoma. In multivariable regression analysis, pathological type with NEC/MANEC was a risk factor for poorer RFS (p = 0.022, hazard ratio: 6.09).CONCLUSIONS:Patients with NEC/MANEC have high malignant potential and poor outcomes. It is necessary to develop an effective approach and postoperative adjuvant treatment for patients with NEC/MANEC.
DOI	10.1159/000508443
PMID	32570243