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HIGUCHI Ryota
Department School of Medicine(Yachiyo Medical Center), School of Medicine Position Assistant Professor |
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| Article types | Original article |
| Language | English |
| Peer review | Non peer reviewed |
| Title | A Comparison of the Pathological Types of Undifferentiated Carcinoma of the Pancreas. |
| Journal | Formal name：Pancreas Abbreviation：Pancreas ISSN code：15364828/08853177 |
| Domestic / Foregin | Foregin |
| Volume, Issue, Page | 49(2),pp.230-235 |
| Author and coauthor | SHIIHARA Masahiro, HIGUCHI Ryota, IZUMO Wataru, FURUKAWA Toru, YAMAMOTO Masakazu |
| Authorship | 2nd author |
| Publication date | 2020/02 |
| Summary | OBJECTIVES:This study aimed to identify the detailed clinicopathological features of undifferentiated carcinoma of the pancreas (UCP).METHODS:We investigated clinical, imaging features and the prognoses of 261 patients; 8 were our patients, and the remainder were identified by searching English-language articles in PubMed.RESULTS:We classified patients with UCP into 3 types based on pathological findings: osteoclast-like giant cell-associated carcinoma, pleomorphic cell carcinoma (PLC), and spindle cell carcinoma. There were no remarkable differences in clinical, radiological features between these 3 types. However, PLCs were significantly more likely to be unresectable than were the other 2 types (P < 0.001). Patients with osteoclast-like giant cell-associated carcinoma achieved the best overall survival (OS) rates (P < 0.001), whereas those with spindle cell carcinoma had significantly longer OS rates than did those with PLC (P = 0.004). These OS patterns were maintained when considering only those patients who underwent resection. Patients with PLC had both lower curative resection and high lymph node metastasis rates (P = 0.029, P = 0.023). Patients who underwent resection had more favorable prognoses than did those who did not.CONCLUSIONS:Surgery is the first choice for resectable UCP. Pleomorphic cell carcinoma is particularly malignant; postoperative treatment should be introduced immediately. |
| DOI | 10.1097/MPA.0000000000001483 |
| PMID | 32011534 |