HIGUCHI Ryota    Department   School of Medicine(Yachiyo Medical Center), School of Medicine    Position   Assistant Professor
Article types	Original article
Language	English
Peer review	Peer reviewed
Title	Impact of Antibodies That React With Liver Tissue and Donor-Specific Anti-HLA Antibodies in Pediatric Idiopathic Posttransplantation Hepatitis.
Journal	Formal name：Transplantation Abbreviation：Transplantation ISSN code：15346080/00411337
Volume, Issue, Page	101(5),pp.1074-1083
Author and coauthor	Hirata Yoshihiro, Yoshizawa Atsushi, Egawa Hiroto, Ueda Daisuke, Okamoto Shinya, Okajima Hideaki, Yurugi Kimiko, Hishida Rie, Hirai Hideyo, Miyagawa-Hayashino Aya, Maekawa Taira, Haga Hironori, Uemoto Sinji
Authorship	2nd author
Publication date	2017/05
Summary	BACKGROUND:The cause of late graft dysfunction has not been elucidated. Although an antibody-mediated reaction is suspected as a potential mechanism, the target antigens have not been clarified.METHODS:To clarify the etiology of idiopathic posttransplantation hepatitis (IPTH), we simultaneously examined the presence of antibodies that react with liver tissue (ARLT) by means of indirect immunofluorescence staining, as well as the presence of donor-specific anti-human leukocyte antigen antibodies (HLA-DSA). A subanalysis of the IPTH group was also performed. Within the IPTH group, the correlation between ARLT titer and clinical data were analyzed.RESULTS:In the sera of patients with IPTH (30 patients), ARLT were found at a significantly higher frequency than in patients without IPTH (42 patients; P < 0.001). Moreover, the ARLT titer appeared to be correlated with the severity of hepatitis or hepatic injury. In contrast, the frequency of HLA-DSA was significantly lower in patients with IPTH than in patients without IPTH (P = 0.001).CONCLUSION:Our findings indicate that ARLT, and not HLA-DSA, profoundly influence the etiology of IPTH.
DOI	10.1097/TP.0000000000001653
PMID	28118175