ヒグチ　リヨウタ   HIGUCHI Ryota   樋口　亮太    所属   医学部 医学科（附属八千代医療センター）    職種   講師
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Genomic sequencing identifies ELF3 as a driver of ampullary carcinoma.
掲載誌名	正式名：Cancer Cell 略　 称：Cancer Cell ISSNコード：15356108/18783686
掲載区分	国外
巻・号・頁	29(2),pp.229-240
著者・共著者	Yachida Shinichi†*, Wood Laura D, Suzuki Masami, Takai Erina, Totoki Yasushi, Kato Mamoru, Luchini Claudio, Arai Yasuhito, Nakamura Hiromi, Hama Natsuko, Elzawahry Asmaa, Hosoda Fumie, Shirota Tomoki, Morimoto Nobuhiko, Hori Kunio, Funazaki Jun, Tanaka Hikaru, Morizane Chigusa, Okusaka Takuji, Nara Satoshi, Shimada Kazuaki, Hiraoka Nobuyoshi, Taniguchi Hirokazu, Higuchi Ryota, Oshima Minoru, Okano Keiichi, Hirono Seiko, Mizuma Masamichi, Arihiro Koji, Yamamoto Masakazu, Unno Michiaki, Yamaue Hiroki, Weiss Matthew J, Wolfgang Christopher L, Furukawa Toru, Nakagama Hitoshi, Vogelstein Bert, Kiyono Tohru, Hruban Ralph H, Shibata Tatsuhiro
発行年月	2016/02
概要	Ampullary carcinomas are highly malignant neoplasms that can have either intestinal or pancreatobiliary differentiation. To characterize somatic alterations in ampullary carcinomas, we performed whole-exome sequencing and DNA copy-number analysis on 60 ampullary carcinomas resected from clinically well-characterized Japanese and American patients. We next selected 92 genes and performed targeted sequencing to validate significantly mutated genes in an additional 112 cancers. The prevalence of driver gene mutations in carcinomas with the intestinal phenotype is different from those with the pancreatobiliary phenotype. We identified a characteristic significantly mutated driver gene (ELF3) as well as previously known driver genes (TP53, KRAS, APC, and others). Functional studies demonstrated that ELF3 silencing in normal human epithelial cells enhances their motility and invasion.
DOI	10.1016/j.ccell.2015.12.012
PMID	26806338