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DEGUCHI Atsuko
Department Graduate School of Medical Science, Graduate School of Medical Science Position Professor |
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| Article types | Review article |
| Language | English |
| Peer review | Peer reviewed |
| Presence of invitation | Invited paper |
| Title | Curcumin targets in inflammation and cancer. |
| Journal | Formal name：Endocrine, metabolic & immune disorders drug targets Abbreviation：Endocr Metab Immune Disord Drug Targets ISSN code：(2212-3873)1871-5303(Linking) |
| Volume, Issue, Page | 15(2),pp.88-96 |
| Author and coauthor | Deguchi Atsuko |
| Authorship | Lead author,Corresponding author |
| Publication date | 2015 |
| Summary | Curcumin (1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione) is commonly used as a spice, food additive or dietary pigment. Accumulating evidence suggests that curcumin has several pharmacologic effects, including anti-inflammatory, anti-oxidant and anti-cancer activities. The molecular mechanisms underlying the targets of curcumin are diverse and involve combinations of multiple signaling pathways, including NF-κB and STAT3 signaling. Thus, curcumin is one of the most promising phytochemicals that target various cancers and inflammation-mediated diseases. Clinical trials have been ongoing or completed for various cancers, including breast, pancreatic and colorectal cancers, and multiple myeloma. In this review, the molecular mechanisms and the issue of bioavailability are mainly discussed. |
| PMID | 25772169 |