遠井 素乃
Department School of Medicine(Tokyo Women's Medical University Adachi Medical Center), School of Medicine Position Assistant Professor |
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Article types | Original article |
Language | English |
Peer review | Peer reviewed |
Title | Long-Term Outcome in Patients With Acute Ischemic Stroke and Heart Failure. |
Journal | Formal name:Circulation journal : official journal of the Japanese Circulation Society Abbreviation:Circ J ISSN code:13474820/13469843 |
Domestic / Foregin | Foregin |
Volume, Issue, Page | pp.Online ahead of print |
Author and coauthor | Takahashi Shuntaro, Ishizuka Kentaro, Hoshino Takao, Mizuno Takafumi, Nishimura Ayako, Toi Sono, Kitagawa Kazuo |
Publication date | 2022/04 |
Summary | BACKGROUND:This study aimed to identify the association between long term functional outcomes and acute ischemic stroke (AIS) in patients with heart failure (HF) in Japan and whether 1-year event risks can be related to these patients.Methods and Results: This was a prospective observational study, and 651 patients registered in the Tokyo Women's Medical University Stroke Registry were classified into the HF and non-HF groups. Functional outcome at 1 year after stroke onset was defined as either good (modified Rankin Scale [mRS] score of 0-2) or poor (mRS score of 3-6). The primary outcome was a composite of major adverse cardiovascular events (MACE), including non-fatal stroke, non-fatal acute coronary syndrome, and vascular death. Patients with HF had a higher poor functional outcome rate at 1 year than those without HF (54.7% vs. 28.2%, P<0.001). Multivariate logistic regression analysis also demonstrated the prevalence of HF was an independent predictor of an mRS score of ≥3 at 1 year after stroke onset (odds ratio, 1.05; 95% confidence interval, 1.00-1.10; P=0.036). Furthermore, patients with HF tended to have a higher risk of MACE and all-cause mortality than those without HF.CONCLUSIONS:AIS patients with HF were associated with poor functional outcome at the 1-year follow up. Further multicenter studies involving a larger number of patients are warranted to verify these results. |
DOI | 10.1253/circj.CJ-21-0937 |
PMID | 35444111 |