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KOGISO Tomomi
Department School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine Position Assistant Professor |
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| Article types | Original article |
| Language | English |
| Peer review | Non peer reviewed |
| Title | The Outcome of Salvage Liver Transplantation and Liver Resection for Recurrent Hepatocellular Carcinoma Using the 5-5-500 Rule, Japanese Extended Liver Transplantation Criteria for Hepatocellular Carcinoma |
| Journal | Formal name：Transplantation proceedings Abbreviation：Transplant Proc ISSN code：18732623/00411345 |
| Domestic / Foregin | Foregin |
| Volume, Issue, Page | 55(4),pp.901-905 |
| Author and coauthor | HIRATA Yoshihiro, KOTERA Yoshihito, KATO Takaaki, ARIIZUMI Shunichi, KOGISO Tomomi, TOKUSHIGE Katsutoshi, HONDA Goro, EGAWA Hiroto |
| Publication date | 2023/05 |
| Summary | BACKGROUND:Liver transplantation (LT) for hepatocellular carcinoma (HCC) is limited to Child-Pugh class C patients according to the Japanese HCC treatment algorithm. However, extended criteria of LT for HCC, known as the 5-5-500 rule, were published in 2019. Hepatocellular carcinoma reportedly has a high recurrence rate after primary treatment. We hypothesized that the outcome of recurrent HCC would be improved if the 5-5-500 rule were adopted for patients with recurrent HCC. We, therefore, analyzed the outcomes of surgical treatment (liver resection [LR] and LT) for recurrent HCC using the 5-5-500 rule in our institute.METHODS:Fifty-two patients younger than 70 years of age received surgical treatment for recurrent HCC using our institute's 5-5-500 rule from 2010 to 2019. We divided these patients into the LR and LT groups in the first study. The 10-year overall survival and re-recurrence-free survival were analyzed. The second study analyzed the risk factors of re-recurrence after surgical treatment for recurrent HCC.RESULTS:In the first study, the background characteristics of the 2 groups (LR and LT) showed no significant difference, except for age and Child-Pugh classification. There was no significant difference in the overall survival between groups (P = .35), but the re-recurrence-free survival in the LR group was significantly shorter than that in the LT group (P < .01). In the second study, the male sex and LR were risk factors of re-recurrence after surgical treatment for recurrent HCC. Child-Pugh's class did not contribute to re-recurrence.CONCLUSIONS:To improve the outcomes of recurrent HCC, LT is the better choice, regardless of the Child-Pugh class. |
| DOI | 10.1016/j.transproceed.2023.04.028 |
| PMID | 37244836 |