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KOGISO Tomomi
Department School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine Position Assistant Professor |
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| Article types | Review article |
| Language | English |
| Peer review | Non peer reviewed |
| Title | The Current View of Nonalcoholic Fatty Liver Disease-Related Hepatocellular Carcinoma. |
| Journal | Formal name：Cancers Abbreviation：Cancers (Basel) ISSN code：20726694/20726694 |
| Domestic / Foregin | Foregin |
| Volume, Issue, Page | 13(3),pp.516 |
| Author and coauthor | KOGISO Tomomi, TOKUSHIGE Katsutoshi |
| Authorship | Lead author,Corresponding author |
| Publication date | 2021/01 |
| Summary | Nonalcoholic fatty liver disease (NAFLD) is the hepatic manifestation of metabolic syndrome and can develop into hepatocellular carcinoma (HCC). The incidence of NAFLD-related HCC, which is accompanied by life-threatening complications, is increasing. Advanced fibrosis and lifestyle-related and metabolic comorbidities, especially obesity and diabetes mellitus, are associated with HCC development. However, HCC is also observed in the non-cirrhotic liver. Often, diagnosis is delayed until the tumor is relatively large and the disease is advanced; an effective screening or surveillance method is urgently required. Recently, the NAFLD/nonalcoholic steatohepatitis (NASH) guidelines of Japan were revised to incorporate new strategies and evidence for the management and surveillance of NAFLD/NASH. Fibrosis must be tested for noninvasively, and the risk of carcinogenesis must be stratified. The treatment of lifestyle-related diseases is expected to reduce the incidence of NAFLD and prevent liver carcinogenesis. |
| DOI | 10.3390/cancers13030516 |
| PMID | 33572797 |