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KOGISO Tomomi
Department School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine Position Assistant Professor |
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| Article types | Original article |
| Language | English |
| Peer review | Non peer reviewed |
| Title | Eradication of hepatitis C virus with direct-acting antivirals improves glycemic control in diabetes: A multicenter study. |
| Journal | Formal name：JGH open : an open access journal of gastroenterology and hepatology Abbreviation：JGH Open ISSN code：23979070/23979070 |
| Domestic / Foregin | Foregin |
| Volume, Issue, Page | 5(2),pp.228-234 |
| Author and coauthor | TAKAHASHI Hirokazu, NAKAHARA Takashi, KOGISO Tomomi, IMAJO Kento, KESSOKU Takaomi, KAWAGUCHI Takumi, IDE Tatsuya, KAWANAKA Miwa, FYOGO Hideyuki, FUJII Hideki, ONO Masafumi, KAMEDA Yoshihiro, SUMIDA Yoshio, ANZAI Keizo, SHIMIZU Masahito, TOEIMURA Takuji, NAKAJIMA Atsushi, TOKUSHIGE Katsutoshi, CHAYAMA Kazuaki, EGUCHI Yuichiro, Japan Study Group of NAFLD (JSG‐NAFLD) |
| Publication date | 2021/02 |
| Summary | Background and Aim:Hepatitis C virus (HCV) infection causes insulin resistance and diabetes as extrahepatic manifestations. We aimed to analyze the effect of HCV eradication by direct-acting antiviral (DAA) agents on glucose tolerance.Methods:The hemoglobin A1c (HbA1c) of 272 patients with HCV infection who achieved a sustained virologic response (SVR) was analyzed at baseline before DAA treatment, at the end of DAA therapy (ETR), and 12 weeks after therapy (Post12W).Results:There were no significant differences in HbA1c between baseline, ETR, and Post12W in the overall patients. When the data were stratified according to the presence or absence of diabetes, median HbA1c significantly decreased from baseline (7.2%) to ETR (6.8%) and Post12W (6.8%) in the 55 patients with diabetes, whereas there were no significant changes in the patients without diabetes. Basal HbA1c, fasting plasma glucose, and age were independently associated with the changes in HbA1c according to multivariate analysis, and the predictive formula for changes in HbA1c was found to be ΔHbA1c (%) = 1.449-0.4* HbA1c (%) + 0.012 × Age (year). There were no changes in body mass in diabetic or nondiabetic patients. In diabetic patients taking medication, 63.4% of patients needed less medication.Conclusions:Eradication of HCV improves glycemic control, indicated by a 0.4% decrease in HbA1c in diabetes. |
| DOI | 10.1002/jgh3.12474 |
| PMID | 33553660 |