ABE Kayoko
   Department   School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine
   Position  
Article types Original article
Language English
Peer review Peer reviewed
Title Quantitative accuracy of computed tomography perfusion under low-dose conditions, measured using a hollow-fiber phantom.
Journal Formal name：Japanese journal of radiology
Abbreviation：Jpn J Radiol
ISSN code：(1867-108X)1867-1071(Linking)
Domestic / ForeginDomestic
Volume, Issue, Page 35(7),pp.373-380
Author and coauthor Suzuki Kazufumi*†, Hashimoto Hiroyuki, Okaniwa Eiji, Iimura Hiroshi, Suzaki Shingo, Abe Kayoko, Sakai Shuji
Publication date 2017/04
Summary Purpose: The purpose of this study was to investigate the quantitative accuracy under low-dose conditions on com- puted tomography (CT) perfusion using a hollow-fiber phantom that had the theoretical absolute values of perfu- sion indices.
Materials and methods: Our phantom comprised two com- ponents, i.e., a hollow-fiber hemodialyzer to pump the diluted contrast material and a surrounding syringe-shaped X-ray-absorbing body to simulate the absorption of X-rays by a brain and cranium. We performed CTP scans on the phantom under various dose conditions ranging from 20 to 140 mA using a 64-row CT scanner, measuring experi- mental cerebral blood flow (CBF), cerebral blood volume (CBV), mean transit time (MTT), and time to peak (TTP) values using a deconvolution algorithm.
Results: The theoretical value of the CBV was within the 95% confidence interval of CBV values measured under 80 mA. The CBV measured under low-dose settings and all CBF values measured were smaller than the theoretically calculated ones, and all MTT values measured were larger. All measured values of the CBV, CBF, MTT, and TTP decreased with an increase in image noise under lower dose conditions.
Conclusion: It is difficult to define a low-dose limit in clini- cal scan conditions because of the complex characteristics of perfusion indices.
DOI 10.1007/s11604-017-0642-y
PMID 28451938