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稲井 俊太
Department School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine Position Assistant Professor |
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| Article types | Original article |
| Language | English |
| Peer review | Peer reviewed |
| Title | Acoustic stimulation promotes the expression of inducible nitric oxide synthase in the vestibule of guinea pigs. |
| Journal | Formal name：Acta oto-laryngologica. Supplementum Abbreviation：Acta Otolaryngol Suppl ISSN code：03655237/03655237 |
| Domestic / Foregin | Foregin |
| Volume, Issue, Page | (553),pp.54-57 |
| Author and coauthor | Watanabe Ken-ichi, Inai Shunta, Hess Alexander, Michel Olaf, Yagi Toshiaki |
| Authorship | 2nd author |
| Publication date | 2004/08 |
| Summary | Loud acoustic stimulation is known to cause inner ear disturbance. We examined immunohistochemically the vestibule of 12 guinea pigs after acoustic stimulation. The animals were divided into two equal groups: a control group and an acoustic stimulation group. The temporal bones were fixed by means of a cardiac infusion of fixative and immunohistochemically stained for inducible nitric oxide synthase (iNOS). The temporal bones in the control group did not show any iNOS. In the acoustic stimulation group, immunoreactivity for iNOS was detected in the supporting cells and sensory cells of the sensory epithelium, in the dark cell areas and in the vestibular ganglion cells. These findings suggest that free radicals are involved in the pathogenesis of noise-induced inner ear damage. Furthermore, free radicals may cause vestibular damage, as is seen in noise-induced inner ear damage. |
| DOI | 10.1080/03655230410017670 |
| PMID | 15277037 |