イナイ　シユンタ   稲井　俊太    所属   医学部 医学科（東京女子医科大学病院）    職種   助教
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Acoustic stimulation promotes the expression of inducible nitric oxide synthase in the vestibule of guinea pigs.
掲載誌名	正式名：Acta oto-laryngologica. Supplementum 略　 称：Acta Otolaryngol Suppl ISSNコード：03655237/03655237
掲載区分	国外
巻・号・頁	(553),pp.54-57
著者・共著者	Watanabe Ken-ichi, Inai Shunta, Hess Alexander, Michel Olaf, Yagi Toshiaki
担当区分	2nd著者
発行年月	2004/08
概要	Loud acoustic stimulation is known to cause inner ear disturbance. We examined immunohistochemically the vestibule of 12 guinea pigs after acoustic stimulation. The animals were divided into two equal groups: a control group and an acoustic stimulation group. The temporal bones were fixed by means of a cardiac infusion of fixative and immunohistochemically stained for inducible nitric oxide synthase (iNOS). The temporal bones in the control group did not show any iNOS. In the acoustic stimulation group, immunoreactivity for iNOS was detected in the supporting cells and sensory cells of the sensory epithelium, in the dark cell areas and in the vestibular ganglion cells. These findings suggest that free radicals are involved in the pathogenesis of noise-induced inner ear damage. Furthermore, free radicals may cause vestibular damage, as is seen in noise-induced inner ear damage.
DOI	10.1080/03655230410017670
PMID	15277037