丸子　一朗
   Department   School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine
   Position   Associate Professor
Article types Original article
Language English
Peer review Peer reviewed
Title Three-month outcomes of faricimab loading therapy for wet age-related macular degeneration in Japan.
Journal Formal name：Scientific reports
Abbreviation：Sci Rep
ISSN code：20452322/20452322
Domestic / ForeginForegin
Volume, Issue, Page 13(1),pp.8747
Author and coauthor Mukai Ryo, Kataoka Keiko, Tanaka Koji, Miyara Yasunori, Maruko Ichiro, Nakayama Makiko, Watanabe Yuto, Yamamoto Akiko, Wakatsuki Yu, Onoe Hajime, Wakugawa Sorako, Terao Nobuhiro, Hasegawa Taiji, Hashiya Nozomu, Kawai Moeko, Maruko Ruka, Itagaki Kanako, Honjo Jyunichiro, Okada Annabelle A, Mori Ryusaburo, Koizumi Hideki, Iida Tomohiro, Sekiryu Tetsuju
Publication date 2023/05
Summary This multicenter study aimed to assess the short-term effectiveness and safety of faricimab in treatment-naïve patients with wet age-related macular degeneration (wAMD) in Japan. We retrospectively reviewed 63 eyes of 61 patients with wAMD, including types 1, 2, and 3 macular neovascularization as well as polypoidal choroidal vasculopathy (PCV). Patients received three consecutive monthly intravitreal injections of faricimab as loading therapy. Over these 3 months, visual acuity improved gradually compared to baseline. Moreover, the central foveal thickness decreased significantly at 1, 2, and 3 months compared to baseline (p < 0.0001). At 3 months after initiation of faricimab therapy, a dry macula (defined as absence of intraretinal or subretinal fluid) was achieved in 82% of the eyes. Complete regression of polypoidal lesions was observed in 52% of eyes with PCV. Subfoveal choroidal thickness also decreased significantly at 1, 2, and 3 months compared to baseline (p < 0.0001). Although retinal pigment epithelium tears developed in two eyes, there were no other ocular or systemic complications observed during the 3 months of loading therapy. In conclusion, loading therapy using faricimab resulted in improved visual acuity and retinal morphology in Japanese patients with wAMD without particular safety issues.
DOI 10.1038/s41598-023-35759-4
PMID 37253802