丸子　一朗
   Department   School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine
   Position   Associate Professor
Article types Original article
Language English
Peer review Peer reviewed
Title Optical Coherence Tomography Angiography Findings of Classic Choroidal Neovascularization in Polypoidal Choroidal Vasculopathy.
Journal Formal name：Retina (Philadelphia, Pa.)
Abbreviation：Retina
ISSN code：15392864/0275004X
Domestic / ForeginForegin
Volume, Issue, Page 42(1),pp.123-128
Author and coauthor Izumi Takahiko †, Koizumi Hideki *, Maruko Ichiro, Hasegawa Taiji, Iida Tomohiro
Publication date 2022/01
Summary PURPOSE:To evaluate the flow signals in subretinal hyperreflective material (SHRM) that represents classic choroidal neovascularization (CNV) on fluorescein angiography (FA) in eyes with polypoidal choroidal vasculopathy (PCV).METHODS:We retrospectively reviewed 20 eyes with PCV that appeared to have classic CNV on FA, accompanied by SHRM on optical coherence tomography (OCT) at the same location. Using OCT angiography (OCTA), we analyzed intrinsic flow signals in the SHRM (cross-sectional B-scans, en-face). The possible association between pretreatment OCTA findings and fibrotic scar formation after anti-vascular endothelial growth factor (VEGF) treatment was evaluated.RESULTS:Six of 20 eyes (30%) showed vascular SHRM; the remaining 14 eyes (70%) showed avascular SHRM at the classic CNV site at baseline. The SHRM corresponded with polypoidal lesions seen on indocyanine green angiography in 5 of 6 eyes with vascular SHRM and in all 14 eyes with avascular SHRM. After anti-VEGF treatment, all 6 eyes with vascular SHRM left a fibrotic scar, while all 14 eyes with avascular SHRM showed no scar formation (P < 0.001).CONCLUSION:Using OCTA, we evaluated the flow signals in SHRM that represented classic CNV in eyes with PCV and successfully differentiated true type 2 macular neovascularization from pseudo classic CNV.
DOI 10.1097/IAE.0000000000003264
PMID 34292224