丸子　一朗
   Department   School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine
   Position   Associate Professor
Article types Original article
Language English
Peer review Peer reviewed
Title Correlation between reduction in macular vessel density and frequency of intravitreal ranibizumab for macular oedema in eyes with branch retinal vein occlusion.
Journal Formal name：The British journal of ophthalmology
Abbreviation：Br J Ophthalmol
ISSN code：14682079/00071161
Domestic / ForeginForegin
Volume, Issue, Page 103(1),pp.72-77
Author and coauthor Hasegawa Taiji, Murakawa Sakura, Maruko Ichiro, Kogure-Katakura Akiko, Iida Tomohiro
Publication date 2019/01
Summary AIM:To determine whether there is a significant correlation between the reduction in macular vessel density and the recurrence of macular oedema in eyes with branch retinal vein occlusion (BRVO).METHODS:We reviewed the medical records of 27 eyes with macular oedema associated with BRVO. All eyes had received pro re nata intravitreal ranibizumab (IVR) injection. A reinjection of ranibizumab was performed when the central foveal thickness was ≥300 µm. At 12 months, patients without additional IVR for the last 4 months were placed in the resolved group, otherwise they were placed in the recurrence group. The macular vessel density in 3×3 mm area centred on the fovea was determined by optical coherence tomography angiography.RESULTS:At 12 months, 11 of the 27 (40.7%) eyes were placed in the resolved group and the other 16 (59.3%) eyes were placed in the recurrence group. The mean macular vessel density reduction in the resolved group was 17.60%±7.88% and that in the recurrence group was 8.12%±7.48% (P=0.0042). The mean number of IVR injections in the resolved group was 2.1±1.1 and that in the recurrence group was 5.1±1.2 (P<0.0001). In all eyes, multivariate analysis showed that the reduction in macular vessel density was significantly and negatively correlated with the number of IVR injections (β=-0.6746, P=0.0028).CONCLUSIONS:A reduction in the macular vessel density was significantly correlated with the number of recurrences of macular oedema associated with BRVO.
DOI 10.1136/bjophthalmol-2017-311499
PMID 29545416