クボタ　ユウイチ   久保田　有一    所属   医学部 医学科（附属足立医療センター）    職種   教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Zinc deficiency may contribute to the severity of acute stroke in elderly patients: results of preliminary study and literature review
掲載誌名	正式名：Tokyo Women’s Medical University Journal, 略　 称：TWMUJ ISSNコード：2432-6186
巻・号・頁	5,pp.64-71
著者・共著者	Kumar Amit†, Kubota Yuichi*, Chernov Mikhail, Kasuya Hidetoshi
担当区分	2nd著者,責任著者
発行年月	2021/12
概要	Background: Zinc (Zn) is highly important for metabolism in humans and its deficiency is associated with various diseases. The present retrospective study has assessed the serum Zn level in cases of acute stroke. Methods: Study cohort included 47 patients (mean age, 73 years) with minor (N = 27), moderate (N = 13), and severe (N = 7) stroke. The National Institutes of Health Stroke Scale (NIHSS) score at admission varied from 1 to 40 (median, 3). Results: Serum Zn level ranged from 23 to 102 μg/dL (mean, 68.4 μg/dL). It inversely correlated with the NIHSS score (P = 0.0340), was associated with the stroke severity (P = 0.0133), was significantly lower in patients with thrombotic stroke (P = 0.0434), and inversely correlated with the age of patient (P = 0.0220). In those aged >74 years (N = 23), but not in younger individuals, serum Zn level inversely correlated with the NIHSS score (P = 0.0155) and was associated with the stroke severity (P = 0.0117). Conclusions: In patients with acute stroke the serum Zn level is frequently decreased. It is associated with the stroke severity, thrombotic type, and older age, and may contribute to more severe clinical course of the disease among the elderly.
DOI	10.24488/twmuj.2020013