HOSHINO Junichi    Department   School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine    Position   Professor and Division head
Article types	Original article
Language	English
Peer review	Non peer reviewed
Title	Adolescent-onset TAFRO Syndrome with Malignant Nephrosclerosis-like Lesions.
Journal	Formal name：Internal medicine (Tokyo, Japan) Abbreviation：Intern Med ISSN code：13497235/09182918
Volume, Issue, Page	62(15),pp.2223-2229
Author and coauthor	Nakayama Yuki, Mizuno Hiroki, Sawa Naoki, Suwabe Tatsuya, Yamanouchi Masayuki, Ikuma Daisuke, Hasegawa Eiko, Hoshino Junichi, Sekine Akinari, Oba Yuki, Kono Kei, Kinowaki Keiichi, Ohashi Kenichi, Suzuki Kodai, Sato Yasuharu, Shimizu Akira, Yamaguchi Yutaka, Ubara Yoshifumi
Publication date	2023/08
Summary	A 16-year-old Japanese girl developed a fever, thrombocytopenia, and renal dysfunction. Treatment was started with steroids, but cervical lymphadenopathy and ascites developed. A lymph node biopsy indicated TAFRO syndrome. The patient's renal function deteriorated, and dialysis was started. Refractory hypertension and subsequent encephalopathy developed. Treatment was started with an anti-IL-6 receptor antibody and an anti-CD20 monoclonal antibody. A kidney biopsy showed malignant nephrosclerosis-like microangiopathy and glomerular collapse due to narrowing of the small arteries. The majority of TAFRO syndrome cases are adult-onset, with glomerular microangiopathy. To our knowledge, this is the first report of adolescent-onset TAFRO syndrome presenting with malignant nephrosclerosis-like lesions associated with hypertension.
DOI	10.2169/internalmedicine.0529-22
PMID	36517029