ホシノ　ジユンイチ   HOSHINO Junichi   星野　純一    所属   医学部 医学科（東京女子医科大学病院）    職種   教授・基幹分野長
論文種別	原著
言語種別	英語
査読の有無	査読なし
表題	Adolescent-onset TAFRO Syndrome with Malignant Nephrosclerosis-like Lesions.
掲載誌名	正式名：Internal medicine (Tokyo, Japan) 略　 称：Intern Med ISSNコード：13497235/09182918
巻・号・頁	62(15),pp.2223-2229
著者・共著者	Nakayama Yuki, Mizuno Hiroki, Sawa Naoki, Suwabe Tatsuya, Yamanouchi Masayuki, Ikuma Daisuke, Hasegawa Eiko, Hoshino Junichi, Sekine Akinari, Oba Yuki, Kono Kei, Kinowaki Keiichi, Ohashi Kenichi, Suzuki Kodai, Sato Yasuharu, Shimizu Akira, Yamaguchi Yutaka, Ubara Yoshifumi
発行年月	2023/08
概要	A 16-year-old Japanese girl developed a fever, thrombocytopenia, and renal dysfunction. Treatment was started with steroids, but cervical lymphadenopathy and ascites developed. A lymph node biopsy indicated TAFRO syndrome. The patient's renal function deteriorated, and dialysis was started. Refractory hypertension and subsequent encephalopathy developed. Treatment was started with an anti-IL-6 receptor antibody and an anti-CD20 monoclonal antibody. A kidney biopsy showed malignant nephrosclerosis-like microangiopathy and glomerular collapse due to narrowing of the small arteries. The majority of TAFRO syndrome cases are adult-onset, with glomerular microangiopathy. To our knowledge, this is the first report of adolescent-onset TAFRO syndrome presenting with malignant nephrosclerosis-like lesions associated with hypertension.
DOI	10.2169/internalmedicine.0529-22
PMID	36517029