ホシノ　ジユンイチ   HOSHINO Junichi   星野　純一    所属   医学部 医学科（東京女子医科大学病院）    職種   教授・基幹分野長
論文種別	原著
言語種別	英語
査読の有無	査読なし
表題	Diagnostic Value of 18F-FDG Positron Emission Tomography and Computed Tomography for differentiating Polymyalgia Rheumatica and Rheumatoid Arthritis: using classification and logistic regression tree (CART) analysis.
掲載誌名	正式名：Modern Rheumatology 略　 称：Modern Rheumatol ISSNコード：14397595
巻・号・頁	pp.online
著者・共著者	Ikuma Daisuke, Sawa Naoki, Yamanouchi Masayuki, Oba Yuki, Mizuno Hiroki, Suwabe Tatsuya, Hoshino Junichi, Ubara Yoshifumi
発行年月	2023/06/06
概要	OBJECTIVES:Determine which sites were important to different polymyalgia rheumatica (PMR) from rheumatoid arthritis (RA) using 18-F fluorodeoxyglucose (FDG) positron emission tomography and computed tomography (PET-CT) is challenging.METHODS:Patients with PMR or RA who were undergoing PET-CT were recruited at two mutual-aid hospitals in Japan between 2009 and 2018. Classification and regression tree (CART) analyses were performed to identify FDG uptake patterns that differentiated PMR from RA.RESULTS:We enrolled 35 patients with PMR and 46 patients with RA. Univariate CART analysis showed that FDG uptake in the shoulder joints, spinous processes of the lumbar vertebrae, pubic symphysis, sternoclavicular joints, ischial tuberosities, greater trochanters, and hip joints differentiated PMR from RA. Multivariate CART analysis revealed that FDG uptake by at least one of the ischial tuberosities had the highest diagnostic value for distinguishing PMR from RA (sensitivity, 77.1%; specificity, 82.6%). We performed the same CART analysis to patients who had not undergone treatment (PMR, n=28; RA, n=9). Similar results were obtained and sensitivity and specificity were increased (sensitivity, 89.3%; specificity, 88.8%).CONCLUSIONS:In PET-CT, FDG uptake by at least one of the ischial tuberosities best discriminates between PMR and RA.
DOI	10.1093/mr/road051
PMID	37279960