HOSHINO Junichi    Department   School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine    Position   Professor and Division head
Article types	Original article
Language	English
Peer review	Non peer reviewed
Title	A Half-Century Dialysis Survivor: Clinical and Autopsy Findings.
Journal	Formal name：Kidney medicine Abbreviation：Kidney Med ISSN code：25900595/25900595
Volume, Issue, Page	5(4),pp.100612
Author and coauthor	Okubo Noto, Suwabe Tatsuya, Oba Yuki, Ikuma Daisuke, Mizuno Hiroki, Sekine Akinari, Hasegawa Eiko, Yamanouchi Masayuki, Hoshino Junichi, Kitajima Izuru, Shiba Masanori, Uruga Koki, Takeshi Fuji, Ohashi Kenichi, Sawa Naoki, Ubara Yoshifumi
Publication date	2023/04
Summary	A man in his 20s initiated intermittent peritoneal dialysis in the late 1960s. He subsequently transitioned to hemodialysis and survived for more than 50 years, spanning low-flux and high-flux hemodialysis eras. He underwent surgery for cervical and lumbar spinal canal stenosis after 30 and 35 years, respectively, and both surgeries revealed similar degrees of severe amyloid deposition. At autopsy, significant improvement was seen in lumbar amyloid deposition. During the previous 25 years, serum β2 microglobulin levels had decreased from 40 mg/L and been maintained at 20 mg/L. This case indicates that advances in dialysis therapy aimed at lowering β2 microglobulin concentrations have reduced highly deposited amyloid.
DOI	10.1016/j.xkme.2023.100612
PMID	36915367