ホシノ　ジユンイチ   HOSHINO Junichi   星野　純一    所属   医学部 医学科（東京女子医科大学病院）    職種   教授・基幹分野長
論文種別	原著
言語種別	英語
査読の有無	査読なし
表題	A Half-Century Dialysis Survivor: Clinical and Autopsy Findings.
掲載誌名	正式名：Kidney medicine 略　 称：Kidney Med ISSNコード：25900595/25900595
巻・号・頁	5(4),pp.100612
著者・共著者	Okubo Noto, Suwabe Tatsuya, Oba Yuki, Ikuma Daisuke, Mizuno Hiroki, Sekine Akinari, Hasegawa Eiko, Yamanouchi Masayuki, Hoshino Junichi, Kitajima Izuru, Shiba Masanori, Uruga Koki, Takeshi Fuji, Ohashi Kenichi, Sawa Naoki, Ubara Yoshifumi
発行年月	2023/04
概要	A man in his 20s initiated intermittent peritoneal dialysis in the late 1960s. He subsequently transitioned to hemodialysis and survived for more than 50 years, spanning low-flux and high-flux hemodialysis eras. He underwent surgery for cervical and lumbar spinal canal stenosis after 30 and 35 years, respectively, and both surgeries revealed similar degrees of severe amyloid deposition. At autopsy, significant improvement was seen in lumbar amyloid deposition. During the previous 25 years, serum β2 microglobulin levels had decreased from 40 mg/L and been maintained at 20 mg/L. This case indicates that advances in dialysis therapy aimed at lowering β2 microglobulin concentrations have reduced highly deposited amyloid.
DOI	10.1016/j.xkme.2023.100612
PMID	36915367