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HOSHINO Junichi
Department School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine Position Professor and Division head |
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| Article types | Original article |
| Language | English |
| Peer review | Non peer reviewed |
| Title | Long-term effectiveness of a primary care practice facilitation program for chronic kidney disease management: an extended follow-up of a cluster-randomized FROM-J study. |
| Journal | Formal name：Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association Abbreviation：Nephrol Dial Transplant ISSN code：14602385/09310509 |
| Volume, Issue, Page | 38(1),pp.158-166 |
| Author and coauthor | Imasawa Toshiyuki, Saito Chie, Kai Hirayasu, Iseki Kunitoshi, Kazama Junichiro James, Shibagaki Yugo, Sugiyama Hitoshi, Nagata Daisuke, Narita Ichiei, Nishino Tomoya, Hasegawa Hajime, Honda Hirokazu, Maruyama Shoichi, Miyazaki Mariko, Mukoyama Masashi, Yasuda Hideo, Wada Takashi, Ishikawa Yuichi, Tsunoda Ryoya, Nagai Kei, Okubo Reiko, Kondo Masahide, Hoshino Junichi, Yamagata Kunihiro |
| Publication date | 2023/01 |
| Summary | BACKGROUND:Practice facilitation program by multidisciplinary care for primary care physicians (PCPs) is expected to improve chronic kidney disease (CKD) outcomes, but there is no clear evidence of its long-term effectiveness. We have previously performed a cluster-randomized controlled trial for 3.5 years (the Frontier of Renal Outcome Modifications in Japan (FROM-J) study) with two arms-group A without the program and group B with the program. We aimed to assess the long-term effectiveness of the practice facilitation program on CKD outcomes via an extended 10-year follow-up of the FROM-J study.METHODS:We enrolled patients who were in the FROM-J study. The primary composite endpoint comprised cardiovascular disease (CVD), renal replacement therapy initiation and a 50% decrease in the estimated glomerular filtration rate (eGFR). The secondary endpoints were survival rate, eGFR decline rate and collaboration rate between PCPs and nephrologists.RESULTS:The occurrence of the primary composite endpoint tended to be lower in group B (group A: 27.1% versus group B: 22.1%, P = 0.051). Furthermore, CVD incidence was remarkably lower in group B (group A: 10.5% versus group B: 6.4%, P = 0.001). Although both mortality and the rate of eGFR decline were identical between both groups, the eGFR decline rate was significantly better in group B than in group A only in patients with stage G3a at enrollment (group A: 2.35 ± 3.87 mL/min/1.73 m2/year versus group B: 1.68 ± 2.98 mL/min/1.73 m2/year, P = 0.02). The collaboration rate was higher in group B.CONCLUSIONS:The CKD practice facilitation program for PCPs reliably decreases CVD events and may reduce the progression of cases to end-stage kidney disease. |
| DOI | 10.1093/ndt/gfac041 |
| PMID | 35195257 |