|
HOSHINO Junichi
Department School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine Position Professor and Division head |
|
| Article types | Case report |
| Language | English |
| Peer review | Peer reviewed |
| Title | A Bone Histomorphometric Analysis of Hypophosphatasia-related Osteoporosis after Teriparatide Treatment. |
| Journal | Formal name：Internal medicine (Tokyo, Japan) Abbreviation：Intern Med ISSN code：13497235/09182918 |
| Volume, Issue, Page | 62(1),pp.75-79 |
| Author and coauthor | Mizuno Hiroki, Sawa Naoki, Sekine Akinari, Inoue Noriko, Oba Yuki, Ikuma Daisuke, Yamanouchi Masayuki, Hasegawa Eiko, Suwabe Tatsuya, Suzuki Hisanori, Hoshino Junichi, Ubara Yoshifumi |
| Publication date | 2023/01/01 |
| Summary | A 79-year-old man was admitted with a compression fracture of the first lumbar vertebra. His alkaline phosphatase (ALP) level was 35 IU/L, and his dual energy X-ray absorptiometry T score was -3.7 standard deviations, indicating osteoporosis. A genetic analysis showed a mutation of the alkaline phosphatase biomineralization-associated gene encoding tissue-nonspecific alkaline phosphatase. Hypophosphatasia-related osteoporosis was diagnosed. Alendronate, teriparatide, and minodronate were administered in that order. The ALP level increased during teriparatide use. A bone biopsy performed after three years of teriparatide treatment showed that cancellous bone was adynamic. In cortical bone, tetracycline double-labeling indicates enhanced bone formation. Teriparatide may thus be a viable treatment option even in patients with hypophosphatasia. |
| DOI | 10.2169/internalmedicine.9624-22 |
| PMID | 35650135 |