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ホシノ ジユンイチ
HOSHINO Junichi
星野 純一 所属 医学部 医学科（東京女子医科大学病院） 職種 教授・基幹分野長 |
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| 論文種別 | 症例報告 |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Endothelial Damage-dominant Nephritis Related to IgA Vasculitis after 11 Years' Use of Infliximab for Rheumatoid Arthritis. |
| 掲載誌名 | 正式名：Internal medicine (Tokyo, Japan) 略 称：Intern Med ISSNコード：13497235/09182918 |
| 掲載区分 | 国外 |
| 巻・号・頁 | 62(1),pp.81-85 |
| 著者・共著者 | Fukuda Makoto, Sawa Naoki, Ikuma Daisuke, Oba Yuki, Mizuno Hiroki, Yamanouchi Masayuki, Sekine Akinari, Hasegawa Eiko, Suwabe Tatsuya, Hoshino Junichi, Kono Kei, Kinowaki Keiichi, Ohashi Kenichi, Tamaki Hiromichi, Miyazono Motoaki, Ubara Yoshifumi |
| 発行年月 | 2023/01/01 |
| 概要 | A 43-year-old Japanese woman with rheumatoid arthritis treated by infliximab and methotrexate for 11 years was admitted for proteinuria and purpura. A kidney biopsy revealed endothelial damage-dominant nephritis with IgA deposition. Infliximab and methotrexate were discontinued, and tocilizumab was started; however, proteinuria persisted. Therefore, tocilizumab was discontinued, and oral prednisolone and methylprednisolone pulse therapy were administered. After 6 months, urinary protein was less than 0.1 g/day, and purpura subsided. To our knowledge, this is the first case of endothelial damage-dominant nephritis related to IgA vasculitis involving the skin and kidney after long-term use of infliximab and methotrexate. |
| DOI | 10.2169/internalmedicine.9059-21 |
| PMID | 35650123 |