HOSHINO Junichi
   Department   School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine
   Position   Professor and Division head
Article types Original article
Language English
Peer review Non peer reviewed
Title Syphilis-associated membranous nephropathy successfully treated with amoxicillin.
Journal Formal name:Clinical nephrology
Abbreviation:Clin Nephrol
ISSN code:03010430/03010430
Domestic / ForeginForegin
Volume, Issue, Page 96(5),pp.297-301
Author and coauthor Hazue Ryo, Ueno Toshiharu, Nozaki Hiroyuki, Kinowaki Keiichi, Ohashi Kenichi, Hoshino Junichi, Sawa Naoki, Ubara Yoshifumi
Publication date 2021/11
Summary A 33-year-old Japanese man with no significant past medical history was admitted to our hospital for evaluation of weight gain and pitting edema. A laboratory test confirmed nephrotic-range proteinuria. Renal biopsy showed subepithelial deposits, and membranous nephropathy (MN) was diagnosed. Closer examination clarified an active syphilis infection. After renal biopsy, we prescribed amoxicillin for 8 weeks to treat the syphilis infection. Three weeks later, the patient's proteinuria dramatically decreased. This case is of interest because syphilis can become a cause of acute-onset MN in younger adults, and the incidence of syphilis is increasing in Japan.
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DOI 10.5414/CN110586
PMID 34448699