ホシノ　ジユンイチ   HOSHINO Junichi   星野　純一    所属   医学部 医学科（東京女子医科大学病院）    職種   教授・基幹分野長
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Echocardiographic Findings and Genotypes in Autosomal Dominant Polycystic Kidney Disease.
掲載誌名	正式名：Kidney diseases (Basel, Switzerland) 略　 称：Kidney Dis (Basel) ISSNコード：22969381/22969357
掲載区分	国外
巻・号・頁	8(3),pp.246-252
著者・共著者	Miyamoto Ryohei, Sekine Akinari, Fujimaru Takuya, Suwabe Tatsuya, Mizuno Hiroki, Hasegawa Eiko, Yamanouchi Masayuki, Chiga Motoko, Mori Takayasu, Sohara Eisei, Uchida Shinichi, Sawa Naoki, Ubara Yoshifumi, Hoshino Junichi
担当区分	最終著者
発行年月	2022/05
概要	BACKGROUND:Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary cystic kidney disease and is well known to have extrarenal complications. Cardiovascular complications are of particular clinical relevance because of their morbidity and mortality; however, unclear is why they occur so frequently in patients with ADPKD and whether they are related to the genotypes.METHODS:We extracted and retrospectively analyzed clinical data on patients with ADPKD who underwent echocardiography and whose genotype was confirmed by genetic testing between April 2016 and December 2020. We used next-generation sequencing to compare cardiac function, structural data, and the presence of cardiac valvular disease in patients with 1 of 3 genotypes: PKD1, PKD2, and non-PKD1, 2.RESULTS:This retrospective study included 65 patients with ADPKD. Patients were divided into 3 groups: PKD1, n = 32; PKD2, n = 12; and non-PKD1, 2, n = 21. The prevalence of mitral regurgitation (MR) was significantly higher in the PKD1 group than in the PKD2 and non-PKD1, 2 group (46.9% vs. 8.3% vs. 19.0%, respectively; p = 0.02). In contrast, no significant difference was found for other cardiac valve complications.CONCLUSION:This study found a significantly higher prevalence of MR in patients with the PKD1 genotype than in those with the PKD2 or non-PKD1, 2 genotypes. Physicians may need to perform echocardiography earlier and more frequently in patients with ADPKD and the PKD1 genotype and to control fluid volume and blood pressure more strictly in these patients to prevent future cardiac events.
DOI	10.1159/000520300
PMID	35702705