タナベ ケンジ
  田邊 賢司
   所属   研究施設 研究施設
   職種   准教授
論文種別 原著
言語種別 英語
査読の有無 査読あり
表題 The carboxy-terminal region of SMAP2 directs subcellular localization as well as Arf protein specificity.
掲載誌名 正式名:Biochemical and biophysical research communications
巻・号・頁 404,661-666頁
著者・共著者 Sakakura, Ikuko Tanabe, Kenji Nouki, Natsumi Suzuki, Mai Satake, Masanobu Watanabe, Toshio
発行年月 2011
概要 Small G proteins play a central role in theorganization of secretory and endocytotic pathways. The recruitment of some effectors, including vesicle coat proteins, is mediated by the ADP-ribosylation factor (Arf) family. Arf proteins have distinct subcellular localizations. ArfGAPs (Arf GTPase-activating proteins) regulate Arf GTPase activity. Thus, each ArfGAP is distinctly localized to allow it to maintain a specific interaction with its target Arf(s). However, the domains that regulate the subcellular localization of ArfGAPs and the way in which these subcellular localizations affect the target specificities of ArfGAPs remain unclear. Recently, we identified two novel ArfGAPs, SMAP1 (Small ArfGAP protein 1) and SMAP2. In the current study, we identified sequences in the carboxy-terminal region of SMAP2 that are critical for its specific subcellular localization and its specificity for Arf proteins.