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AKAGAWA HIROYUKI
Department Research Institutes and Facilities, Research Institutes and Facilities Position Associate Professor |
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| Article types | Original article |
| Language | English |
| Peer review | Peer reviewed |
| Title | Using endothelial nitric oxide synthase gene polymorphisms to identify intracranial aneurysms more prone to rupture in Japanese patients. |
| Journal | Formal name：Journal of neurosurgery Abbreviation：J Neurosurg ISSN code：(0022-3085)0022-3085(Linking) |
| Domestic / Foregin | Foregin |
| Volume, Issue, Page | 105(5),pp.717-22 |
| Author and coauthor | Krischek Boris, Kasuya Hidetoshi, Akagawa Hiroyuki, Tajima Atsushi, Narita Akira, Onda Hideaki, Hori Tomokatsu, Inoue Ituro |
| Publication date | 2006/11 |
| Summary | The three eNOS polymorphisms were genotyped in 297 patients with ruptured aneurysms (RAs), 108 patients with unruptured aneurysms (UAs), and 176 healthy volunteers by using polymerase chain reaction. The distribution of the variant alleles did not differ significantly (p > 0.05) between the RA group and the UA group. The frequency of the corresponding genotypes between the two groups and a haplotype analysis did not show any significant differences. Further comparisons of the RA and UA groups with the control group did not yield any significant allele or genotype frequency differences. Conclusions. These data show that the examined set of eNOS polymorphisms were not indicative of which Japanese patients with intracranial aneurysms would suffer an SAH. The presence of eNOS polymorphisms is not useful in identifying intracranial aneurysms that are more prone to rupture in a Japanese patient sample. |
| DOI | 10.3171/jns.2006.105.5.717 |
| PMID | 17121133 |