アカガワ　ヒロユキ   AKAGAWA HIROYUKI   赤川　浩之    所属   研究施設 研究施設    職種   准教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Using endothelial nitric oxide synthase gene polymorphisms to identify intracranial aneurysms more prone to rupture in Japanese patients.
掲載誌名	正式名：Journal of neurosurgery 略　 称：J Neurosurg ISSNコード：(0022-3085)0022-3085(Linking)
掲載区分	国外
巻・号・頁	105(5),pp.717-22
著者・共著者	Krischek Boris, Kasuya Hidetoshi, Akagawa Hiroyuki, Tajima Atsushi, Narita Akira, Onda Hideaki, Hori Tomokatsu, Inoue Ituro
発行年月	2006/11
概要	The three eNOS polymorphisms were genotyped in 297 patients with ruptured aneurysms (RAs), 108 patients with unruptured aneurysms (UAs), and 176 healthy volunteers by using polymerase chain reaction. The distribution of the variant alleles did not differ significantly (p > 0.05) between the RA group and the UA group. The frequency of the corresponding genotypes between the two groups and a haplotype analysis did not show any significant differences. Further comparisons of the RA and UA groups with the control group did not yield any significant allele or genotype frequency differences. Conclusions. These data show that the examined set of eNOS polymorphisms were not indicative of which Japanese patients with intracranial aneurysms would suffer an SAH. The presence of eNOS polymorphisms is not useful in identifying intracranial aneurysms that are more prone to rupture in a Japanese patient sample.
DOI	10.3171/jns.2006.105.5.717
PMID	17121133