アカガワ　ヒロユキ   AKAGAWA HIROYUKI   赤川　浩之    所属   研究施設 研究施設    職種   准教授
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Influence of endothelial nitric oxide synthase T-786C single nucleotide polymorphism on aneurysm size.
掲載誌名	正式名：Journal of neurosurgery 略　 称：J Neurosurg ISSNコード：0022-3085(Print)0022-3085(Linking)
掲載区分	国外
巻・号・頁	102(1),pp.68-71
著者・共著者	Akagawa Hiroyuki, Kasuya Hidetoshi, Onda Hideaki, Yoneyama Taku, Sasahara Atsushi, Kim Chul-Jin, Lee Jung-Chung, Yang Tae-Ki, Hori Tomokatsu, Inoue Ituro
担当区分	筆頭著者
発行年月	2005/01
概要	OBJECT:Among patients with aneurysms, those with heterozygous (T/C) endothelial nitric oxide synthase (eNOS) T-786C single nucleotide polymorphism (SNP), a mutation reducing endothelial nitric oxide synthesis, are reported to have larger ruptured intracranial aneurysms (IAs) than those with homozygous (C/C or T/T) genotype. The authors tested patients harboring aneurysms for eNOS T-786C SNP in two populations--Japanese and Korean.METHODS:The eNOS T-786C SNP was genotyped through direct sequencing in genomic DNA obtained from 336 Japanese and 191 Korean patients with lAs and 214 Japanese and 191 Korean control volunteers. Differences in genotype frequencies among the various aneurysm sizes were evaluated using the Fisher exact test. There was no significant difference in heterozygous (T/C) eNOS T-786C SNP between aneurysms 5 mm or smaller and those from 6 to 9 mm, and between lesions 5 mm or smaller and those 10 mm or larger in 336 Japanese patients harboring aneurysms--220 with ruptured and 116 with unruptured lesions--and in 191 Korean patients with ruptured aneurysms.CONCLUSION:The eNOS T-786C SNP genotype does not influence the size of aneurysms.
DOI	10.3171.jns.2005.102.1.0068
文献番号	15658098