AKAGAWA HIROYUKI    Department   Research Institutes and Facilities, Research Institutes and Facilities    Position   Associate Professor
Article types	Original article
Language	English
Peer review	Peer reviewed
Title	Is there any evidence for linkage on chromosome 17cen in affected Japanese sib-pairs with an intracranial aneurysm?
Journal	Formal name：Journal of human genetics Abbreviation：J Hum Genet ISSN code：1434-5161(Print)1434-5161(Linking)
Volume, Issue, Page	51(5),pp.491-4
Author and coauthor	Krischek Boris, Narita Akira, Akagawa Hiroyuki, Kasuya Hidetoshi, Tajima Atsushi, Onda Hideaki, Yoneyama Taku, Hori Tomokatsu, Inoue Ituro
Publication date	2006/05
Summary	A linkage region on chromosome 17cen has previously been found in 29 Japanese families with a history of familial intracranial aneurysms (IA). To investigate whether there is evidence of linkage in affected Japanese sib-pairs we performed nonparametric and parametric linkage analysis of a total of 253 familial aneurysm cases including 111 affected sib-pairs (ASP). Ten microsatellite markers covering a 17.7 cM region were chosen, in accordance with previous work in which nominal P had been below 0.05. Statistical analysis was performed by use of Genehunter and Sibpal software. After calculation of the logarithm of the odds (LOD) and nonparametric linkage analysis (NPL) scores our study did not show any linkage in the region analyzed. Our conclusion did not change even after only ASP were analyzed. In contrast with a previous study examining multigenerational Japanese families with IA, most Japanese ASP may not have a genetic linkage to chromosome 17cen.
DOI	10.1007/s10038-006-0379-4
Document No.	16544051