AKAGAWA HIROYUKI    Department   Research Institutes and Facilities, Research Institutes and Facilities    Position   Associate Professor
Article types	Original article
Language	English
Peer review	Peer reviewed
Title	Association of positional and functional candidate genes FGF1, FBN2, and LOX on 5q31 with intracranial aneurysm.
Journal	Formal name：Journal of human genetics Abbreviation：J Hum Genet ISSN code：1434-5161(Print)1434-5161(Linking)
Volume, Issue, Page	48(6),pp.309-314
Author and coauthor	Yoneyama Taku, Kasuya Hidetoshi, Onda Hideaki, Akagawa Hiroyuki, Jinnai Nobuyoshi, Nakajima Toshiaki, Hori Tomokatsu, Inoue Ituro
Publication date	2003/07
Summary	We previously performed a genome-wide linkage study of intracranial aneurysm (IA) and found positive evidence of linkage at chromosomes 5q22-31, 7q11, and 14q22. In the present study, we focus on 5q31, where three candidate genes, fibroblast growth factor 1 (FGF1), fibrillin 2 (FBN2), and lysyl oxidase gene ( LOX) lie, and evaluate associations with IA. Genomic DNAs were obtained from 172 IA patients and 192 controls. Association analysis was performed with ten, five, and four single-nucleotide polymorphisms (SNPs) identified in FGF1, FBN2, and LOX, respectively. A difference in allelic frequency was observed for only the SNP at intron 4 in FGF1 (chi(2)=4.44, df=1, P=0.035). Although a haplotype association was observed with the combination of ten SNPs in FGF1 (chi(2)=16.04, df=1, P=0.00006), significant haplotype associations were not observed when haplotypes were constructed with the three, two, and four SNPs in FGF1 according to the linkage disequilibrium structure. No associations of FBN2 and LOX with IA were detected in the present study.
DOI	10.1007/s10038-003-0030-6
Document No.	12750963