ISHIYAMA Midori    Department   School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine    Position   Assistant Professor
Article types	Original article
Language	English
Peer review	Peer reviewed
Title	Very Early Increased Platelet Count within a Week after Initiation of High-Dose Dexamethasone Treatment Is Associated with Long-Term Response in Newly Diagnosed Immune Thrombocytopenia Patients.
Journal	Formal name：Acta haematologica Abbreviation：Acta Haematol ISSN code：14219662/00015792
Domestic / Foregin	Foregin
Volume, Issue, Page	145(2),pp.193-200
Author and coauthor	Ishiyama Midori†, Shiseki Masayuki, Yoshinaga Kentaro, Ryuzaki Michiko, Izuka Yuki, Watanabe Aya, Tanaka Norina, Shinohara Akihito, Hagiwara Shotaro, Tanaka Junji
Authorship	Lead author
Publication date	2022/02
Summary	To evaluate the long-term efficacy of high-dose dexamethasone (HD-DXM) treatment for immune thrombocytopenia (ITP), we retrospectively analysed 36 newly diagnosed ITP patients treated with HD-DXM as a first-line treatment. An initial response was obtained in 23 (63.9%) patients, including 11 with a complete response (CR) and 12 with a partial response (PR). Six months after HD-DXM treatment, 26 of 33 (78.8%) evaluable patients achieved objective responses, including 18 CR and 8 PR. Among 13 patients without initial response, very early increased platelet count within a week (VEIP) was observed in 7 patients, 5 (71.4%) of whom achieved a response at 6 months. In 29 patients who had available platelet count within a week, patients showing VEIP revealed longer survival than those who did not (p = 0.026). HD-DXM was an effective treatment for newly diagnosed ITP patients. VEIP after HD-DXM treatment initiation was associated with a long-term objective response in newly diagnosed ITP patients.
DOI	10.1159/000518744
PMID	34818223