|
ISHIYAMA Midori
Department School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine Position Assistant Professor |
|
| Article types | Case report |
| Language | English |
| Peer review | Peer reviewed |
| Title | Successful Rituximab Treatment in Thrombotic Thrombocytopenic Purpura Patients Complicated by Other Autoimmune Disorders: Two Case Reports. |
| Journal | Formal name：Internal medicine (Tokyo, Japan) Abbreviation：Intern Med ISSN code：13497235/09182918 |
| Domestic / Foregin | Foregin |
| Volume, Issue, Page | 60(17),pp.2859-2862 |
| Author and coauthor | Watanabe Aya†, Shiseki Masayuki, Oishi Megumi, Kobayashi Maya, Oshima Shoko, Osanai Satoko, Ryuzaki Michiko, Izuka Yuki, Tanaka Norina, Ishiyama Midori, Shinohara Akihito, Kazama Hiroshi, Hagiwara Shotaro, Yoshinaga Kentaro, Tanaka Junji |
| Publication date | 2021/09 |
| Summary | We herein report two cases of thrombotic thrombocytopenic purpura (TTP) complicated by other autoimmune disorders, autoimmune hepatitis and immune thrombocytopenia, respectively. In both cases, corticosteroids were continuously administered for the treatment of preceding autoimmune disorders. However, a sufficient objective response for TTP was not obtained by plasma exchange and corticosteroid treatment. Once a week rituximab (375 mg/m2) treatment for 4 times was initiated within 2 weeks from the diagnosis. Both patients achieved a sufficient response, and have never had any recurrence as of the last follow-up dates. The early introduction of rituximab could be an effective treatment option in TTP patients complicated with other autoimmune disorders. |
| DOI | 10.2169/internalmedicine.6387-20 |
| PMID | 33775998 |