勝又　康弘
   Department   School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine
   Position   Assistant Professor
Article types Original article
Language English
Peer review Peer reviewed
Title Trends in actual medication use for child-onset systemic lupus erythematosus using the Japanese health insurance database 2009-18.
Journal Formal name：Modern rheumatology
Abbreviation：Mod Rheumatol
ISSN code：14397609/14397595
Domestic / ForeginForegin
Volume, Issue, Page 32(3),pp.565-570
Author and coauthor Kishi Takayuki, Sakai Ryoko, Tani Yumi, Nagata Satoru, Katsumata Yasuhiro, Miyamae Takako, Harigai Masayoshi
Publication date 2022/04
Summary OBJECTIVES:Immunosuppressive therapy is the mainstay of treatment for child-onset systemic lupus erythematosus (cSLE). Since epidemiological data on Japanese cSLE patients are not available, we evaluated the trends in how treatment choices have changed over time in Japan.METHODS:Using the Japanese health insurance database provided by Medical Data Vision Co., Ltd, we identified cSLE patients and evaluated changes in the use of corticosteroids and immunosuppressive medications and maximum daily doses of prednisolone from 2009 to 2018.RESULTS:Of 182 cSLE patients, 86% were female, and the median age was 14 years. Oral prednisolone was used in more than 97% of cSLE patients during the study period, and the median of the maximum daily dose in each patient decreased over time. Intravenous cyclophosphamide was used less frequently after 2016, while mycophenolate mofetil and hydroxychloroquine were used frequently after 2016. The use of mizoribine reduced after 2014, whereas the other immunosuppressive medications showed no significant change over time; the use of biological agents was very limited.CONCLUSIONS:Oral prednisolone was the mainstay of treatment for cSLE, and the maximum daily dose has reduced over the past decade. The most frequently prescribed immunosuppressive therapy has shifted to mycophenolate mofetil over time.
DOI 10.1093/mr/roab038
PMID 34908147