MIZUNO Satoko
   Department   School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine
   Position   Assistant Professor
Article types Case report
Language English
Peer review Peer reviewed
Title Adversive seizures associated with periodic lateralised epileptiform discharges (PLEDs) after left orbital contusion.
Journal Formal name:Epileptic disorders : international epilepsy journal with videotape
Abbreviation:Epileptic Disord
ISSN code:12949361/12949361
Domestic / ForeginForegin
Volume, Issue, Page 14(4),pp.422-5
Author and coauthor Takeda Takahiro, Osawa Mikio, Toi Sono, Mizuno Satoko, Shimizu Yuko, Uchiyama Shinichiro
Publication date 2012/12
Summary We report a patient who presented with adversive seizures associated with periodic lateralised epileptiform discharges (PLEDs), a month after head trauma. The PLEDs predominantly involving the left frontal contacts became more frequent at the onset of adversive seizures during EEG. Brain MRI demonstrated a contusion scar in the left orbital cortex with reduced diffusion, not only around this orbital lesion but also in the ipsilateral anteromedial thalamus. Single photon emission computed tomography revealed focal cerebral hyperperfusion in the left medial orbitofrontal region, basal ganglia, and thalamus. The abnormal metabolism involving the thalamus and striatum could be associated with the ipsilateral orbital contusion and might have been caused by cortical-subcortical, trans-synaptic hyperactivity. Further studies are warranted to determine the role of subcortical structures in the generation of PLEDs and adversive seizures. [Published with video sequences].
DOI 10.1684/epd.2012.0537
PMID 23247965