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MIZUNO Satoko
Department School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine Position Assistant Professor |
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| Article types | Case report |
| Language | English |
| Peer review | Peer reviewed |
| Title | Adversive seizures associated with periodic lateralised epileptiform discharges (PLEDs) after left orbital contusion. |
| Journal | Formal name：Epileptic disorders : international epilepsy journal with videotape Abbreviation：Epileptic Disord ISSN code：12949361/12949361 |
| Domestic / Foregin | Foregin |
| Volume, Issue, Page | 14(4),pp.422-5 |
| Author and coauthor | Takeda Takahiro, Osawa Mikio, Toi Sono, Mizuno Satoko, Shimizu Yuko, Uchiyama Shinichiro |
| Publication date | 2012/12 |
| Summary | We report a patient who presented with adversive seizures associated with periodic lateralised epileptiform discharges (PLEDs), a month after head trauma. The PLEDs predominantly involving the left frontal contacts became more frequent at the onset of adversive seizures during EEG. Brain MRI demonstrated a contusion scar in the left orbital cortex with reduced diffusion, not only around this orbital lesion but also in the ipsilateral anteromedial thalamus. Single photon emission computed tomography revealed focal cerebral hyperperfusion in the left medial orbitofrontal region, basal ganglia, and thalamus. The abnormal metabolism involving the thalamus and striatum could be associated with the ipsilateral orbital contusion and might have been caused by cortical-subcortical, trans-synaptic hyperactivity. Further studies are warranted to determine the role of subcortical structures in the generation of PLEDs and adversive seizures. [Published with video sequences]. |
| DOI | 10.1684/epd.2012.0537 |
| PMID | 23247965 |